Relationship between disease activity and ANCA level by ELISA in the long-term management of vasculitis

Adv Exp Med Biol. 1993;336:303-4. doi: 10.1007/978-1-4757-9182-2_47.


Solid-phase immunoassays were used to examine the relationship between ANCA concentration and disease activity during follow-up of 63 patients with systemic vasculitis. ANCA levels fell with induction therapy. Relapses during long-term follow-up were generally associated with high or rising ANCA concentrations, although the temporal relationship between clinical relapse and changes in ANCA was variable.

MeSH terms

  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies / blood*
  • Cyclophosphamide / therapeutic use
  • Humans
  • Immunoglobulin G / blood*
  • Prednisolone / therapeutic use
  • Recurrence
  • Vasculitis / blood*
  • Vasculitis / drug therapy*


  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies
  • Immunoglobulin G
  • Cyclophosphamide
  • Prednisolone