Orbital involvement in Wegener's granulomatosis

Adv Exp Med Biol. 1993;336:315-7. doi: 10.1007/978-1-4757-9182-2_50.


Orbital granulomas may complicate the course of Wegener's granulomatosis (WG). Granulomas that grow and compress the optic nerve may lead to blindness. Careful magnetic resonance imaging (MRI) is recommended for early detection and follow-up of intraorbital granulomas. Sufficient systemic immunosuppressive treatment should be given as usual for Wegener's granulomatosis. In order to preserve vision orbital decompression may be necessary in rapidly progressive pseudotumor of the orbit.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies / blood
  • Blindness / etiology
  • Cyclophosphamide / therapeutic use
  • Female
  • Granulomatosis with Polyangiitis / complications*
  • Granulomatosis with Polyangiitis / drug therapy
  • Humans
  • Immunoglobulin G / blood
  • Male
  • Optic Nerve Diseases / etiology
  • Orbital Diseases / etiology*
  • Prednisolone / therapeutic use


  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies
  • Immunoglobulin G
  • Cyclophosphamide
  • Prednisolone