Alpha-1-antitrypsin, CRP and interleukin-6 in ANCA-positive vasculitis

Adv Exp Med Biol. 1993;336:337-40. doi: 10.1007/978-1-4757-9182-2_55.


Alfa-1-antitrypsin (a-1-AT), C-reactive protein (CRP) and interleukin-6 (IL-6) serum levels were measured during different phases of anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis. Correlation between ANCA and these variables was observed. Both a-1-AT and CRP fluctuations indicated changes in activity that could not always be detected by ANCA. On the other hand, these acute phase proteins were also less specific. IL-6 was not as sensitive as CRP and a-1-AT, a clearly increased mean value was observed only in patients with high ANCA titers.

MeSH terms

  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies / blood*
  • C-Reactive Protein / metabolism*
  • Humans
  • Immunoglobulin G / blood*
  • Interleukin-6 / metabolism*
  • Vasculitis / blood*
  • Vasculitis / immunology
  • alpha 1-Antitrypsin / metabolism*


  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies
  • Immunoglobulin G
  • Interleukin-6
  • alpha 1-Antitrypsin
  • C-Reactive Protein