Anti-neutrophil cytoplasm antibodies in HIV infection

Adv Exp Med Biol. 1993;336:349-52. doi: 10.1007/978-1-4757-9182-2_58.

Abstract

Sera from 105 HIV-infected patients were tested for anti-neutrophil cytoplasm antibodies (ANCA) by indirect immunofluorescence (IIF), by specific ELISAs using target proteins of ANCA and by a neutrophil cytoplasm extract ELISA. Forty-four sera were positive. These included 18 positive by IIF, 7 with anti-neutrophil proteinase 3 antibodies, 26 with anti-myeloperoxidase antibodies and 2 with anti-elastase antibodies. Four sera were positive in the neutrophil cytoplasm extract ELISA but not in the specific ELISAs. None of these patients had clinical evidence of a cutaneous or systemic vasculitis. In addition there was no correlation between the presence of ANCA and the stage of disease, intercurrent bacterial or viral infection, anti-nuclear antibodies (ANA) and positive hepatitis B or syphilis serology.

MeSH terms

  • AIDS-Related Complex / immunology
  • Acquired Immunodeficiency Syndrome / immunology
  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies / blood*
  • Enzyme-Linked Immunosorbent Assay
  • Fluorescent Antibody Technique
  • HIV Infections / immunology*
  • Humans
  • Immunoglobulin G / blood*
  • Myeloblastin
  • Pancreatic Elastase / immunology
  • Peroxidase / immunology
  • Serine Endopeptidases / immunology

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies
  • Immunoglobulin G
  • Peroxidase
  • Serine Endopeptidases
  • Pancreatic Elastase
  • Myeloblastin