Treatment of Wegener's granulomatosis with intravenous immunoglobulin

Adv Exp Med Biol. 1993;336:487-9. doi: 10.1007/978-1-4757-9182-2_88.

Abstract

We report about the treatment of eight patients with Wegener's granulomatosis and one patient with systemic pANCA-associated vasculitis with a single course of high-dose intravenous immunoglobulin (IVIG). In 5 of 9 patients (55%) this resulted in significant clinical improvement, in two patients a decrease of the ANCA-titre was seen.

MeSH terms

  • Adult
  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies / blood
  • Autoantibodies / immunology
  • Granulomatosis with Polyangiitis / immunology
  • Granulomatosis with Polyangiitis / therapy*
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin G / immunology
  • Immunoglobulins, Intravenous / administration & dosage
  • Immunoglobulins, Intravenous / therapeutic use*
  • Middle Aged
  • Myeloblastin
  • Serine Endopeptidases / immunology
  • Vasculitis / immunology
  • Vasculitis / therapy

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies
  • Immunoglobulin G
  • Immunoglobulins, Intravenous
  • Serine Endopeptidases
  • Myeloblastin