T-cell autoimmunity in type 1 diabetes mellitus

Curr Opin Immunol. 1993 Dec;5(6):903-9. doi: 10.1016/0952-7915(93)90104-z.


Insulin dependent diabetes mellitus is a T-cell mediated autoimmune disease. Several beta-cell antigens, mostly non-tissue-specific, have been implicated in the disease process. The antigens and the autoimmune T cells exist in healthy individuals, as do many of the genes required for the development of diabetes. The question, then, is why and how exposure to undefined environmental agents activates an existing autoimmune potential and directs it to damage the beta cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoantigens / immunology
  • Autoimmunity / immunology*
  • Diabetes Mellitus, Type 1 / immunology*
  • Diabetes Mellitus, Type 1 / prevention & control
  • Humans
  • Major Histocompatibility Complex
  • Mice
  • Mice, Inbred NOD
  • Rats
  • Rats, Inbred BB
  • T-Lymphocytes / immunology*


  • Autoantigens