Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 5 (4), 376-80

Molecular Modelling of the Norrie Disease Protein Predicts a Cystine Knot Growth Factor Tertiary Structure

Affiliations

Molecular Modelling of the Norrie Disease Protein Predicts a Cystine Knot Growth Factor Tertiary Structure

T Meitinger et al. Nat Genet.

Abstract

The X-lined gene for Norrie disease, which is characterized by blindness, deafness and mental retardation has been cloned recently. This gene has been thought to code for a putative extracellular factor; its predicted amino acid sequence is homologous to the C-terminal domain of diverse extracellular proteins. Sequence pattern searches and three-dimensional modelling now suggest that the Norrie disease protein (NDP) has a tertiary structure similar to that of transforming growth factor beta (TGF beta). Our model identifies NDP as a member of an emerging family of growth factors containing a cystine knot motif, with direct implications for the physiological role of NDP. The model also sheds light on sequence related domains such as the C-terminal domain of mucins and of von Willebrand factor.

Similar articles

See all similar articles

Cited by 28 articles

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources

Feedback