Genetics of mouse antibodies. I. Linkage of the dextran response locus, VH-DEX, to allotype

Eur J Immunol. 1975 Nov;5(11):775-7. doi: 10.1002/eji.1830051109.

Abstract

The antibody response of mice to alpha-1,3 linked dextran is shown to be controlled by a heavy chain variable region gene, VH-DEX. The map distance between this gene and the heavy chain allotype locus is estimated to be 0.3 recombination units.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies / genetics*
  • Binding Sites, Antibody / genetics*
  • Chromosome Mapping
  • Crosses, Genetic
  • Dextrans / immunology*
  • Genetic Linkage*
  • Immunoglobulin Allotypes*
  • Immunoglobulin Heavy Chains*
  • Immunoglobulin Variable Region / genetics*
  • Mice
  • Mice, Inbred AKR
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Recombination, Genetic

Substances

  • Antibodies
  • Dextrans
  • Immunoglobulin Allotypes
  • Immunoglobulin Heavy Chains
  • Immunoglobulin Variable Region