A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

Eur J Immunol. 1994 Feb;24(2):429-34. doi: 10.1002/eji.1830240224.


We have found a new spontaneous autosomal recessive mutation in mice that causes a systemic absence of lymph nodes and Peyer's patches. The name "alymphoplasia", with the gene symbol "aly", is proposed for this mutant. The spleen of aly/aly mice is devoid of well-defined lymphoid follicles, and the thymus does not show a clear cortical-medullary distinction. The mutant homozygotes are deficient in both humoral and cell-mediated immune functions, and are highly susceptible to infections. They have a reduced level of IgM and severely depressed levels of IgG and IgA in their sera, and do not reject allogeneic skin grafts. However, they have mature T and B cells as determined from their cell surface antigens. The results of bone marrow transplantation experiments suggest a mesenchymal disorder as a possible cause of the lack of lymph nodes and of immunodeficiency in the aly mouse. The aly mutant mouse may be a useful animal model of primary immunodeficiency, as are the nu (nude) and scid (severe combined immunodeficiency) mice.

MeSH terms

  • Animals
  • Bone Marrow Transplantation / immunology
  • H-2 Antigens / analysis
  • Immunologic Deficiency Syndromes / genetics
  • Immunologic Deficiency Syndromes / immunology*
  • Immunologic Deficiency Syndromes / pathology
  • Immunophenotyping
  • Lymph Nodes / abnormalities*
  • Lymphoid Tissue / pathology
  • Mice
  • Mice, Inbred C57BL
  • Mutation


  • H-2 Antigens