Body fat in Laron syndrome patients: effect of insulin-like growth factor I treatment

Horm Res. 1993;40(1-3):16-22. doi: 10.1159/000183762.


Changes in body fat mass were studied in 25 untreated patients with Laron syndrome from childhood into adulthood. It was found that these patients, characterized by marked dwarfism, high plasma hGH and low serum insulin-like growth factor I (IGF-I), develop progressive and marked obesity and have a tendency for elevated serum cholesterol levels. Long-term treatment of 8 children and 5 adults with this syndrome with IGF-I (50-150 micrograms/kg/day s.c.) resulted in a significant decrease in subcutaneous fat in all patients and a lowering of the serum cholesterol and triglycerides, mainly in the adults. As in Laron syndrome the GH receptors are inactive, it is hypothesized that IGF-I exerts a direct effect on adipose tissue metabolism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / diagnostic imaging
  • Adipose Tissue / pathology*
  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Cholesterol / blood
  • Dwarfism / pathology*
  • Endocrine System Diseases / drug therapy*
  • Endocrine System Diseases / genetics
  • Endocrine System Diseases / pathology*
  • Female
  • Growth Hormone / physiology*
  • Humans
  • Insulin-Like Growth Factor I / deficiency
  • Insulin-Like Growth Factor I / therapeutic use*
  • Lipoproteins / blood
  • Male
  • Obesity / pathology*
  • Skinfold Thickness
  • Syndrome
  • Tomography, X-Ray Computed


  • Lipoproteins
  • Insulin-Like Growth Factor I
  • Growth Hormone
  • Cholesterol