Interaction with 2(4)-thio-5-fluoro-dUMP of thymidylate synthases with differing sensitivities to 5-fluoro-dUMP

Adv Exp Med Biol. 1993:338:617-20. doi: 10.1007/978-1-4615-2960-6_127.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drug Resistance
  • Fluorodeoxyuridylate / analogs & derivatives*
  • Fluorodeoxyuridylate / pharmacology*
  • Hymenolepis / enzymology*
  • Kinetics
  • Leukemia L1210 / enzymology*
  • Liver Regeneration
  • Mice
  • Rats
  • Species Specificity
  • Thionucleotides / pharmacology*
  • Thymidylate Synthase / antagonists & inhibitors*

Substances

  • Thionucleotides
  • 5-fluoro-4-thio-2'-deoxyuridylate
  • Fluorodeoxyuridylate
  • 5-fluoro-2-thio-2'-deoxyuridylate
  • Thymidylate Synthase