Determinants of the disparate antitumor effects of (6R)5,10-dideaza-5,6,7,8- tetrahydrofolate and methotrexate toward methotrexate resistant CCRF-CEM cells, characterized by severely impaired antifolate membrane transport

Adv Exp Med Biol. 1993:338:783-6. doi: 10.1007/978-1-4615-2960-6_164.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents / toxicity*
  • Carrier Proteins / metabolism*
  • Cell Line
  • Drug Resistance
  • Folate Receptors, GPI-Anchored
  • Folic Acid Antagonists / metabolism*
  • Folic Acid Antagonists / toxicity*
  • Humans
  • Kinetics
  • Methotrexate / metabolism
  • Methotrexate / toxicity*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Receptors, Cell Surface / metabolism*
  • Tetrahydrofolates / metabolism
  • Tetrahydrofolates / toxicity*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Carrier Proteins
  • Folate Receptors, GPI-Anchored
  • Folic Acid Antagonists
  • Receptors, Cell Surface
  • Tetrahydrofolates
  • lometrexol
  • Methotrexate