Programmed cell death, apoptosis and killer genes

Immunol Today. 1993 Dec;14(12):582-90. doi: 10.1016/0167-5699(93)90197-S.


A cursory examination of the literature reveals that the study of programmed cell death and apoptosis is increasing exponentially. Most contributors to this field have come either from developmental biology or immunology and view programmed cell death from different perspectives, leading both to confusion and an inability to fully appreciate the literature from other disciplines. Here, Lawrence Schwartz and Barbara Osborne define the terms and ideas relevant to the study of cell death in a way that will be accessible to investigators from all fields.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / genetics*
  • Apoptosis / immunology
  • Cell Death / genetics
  • Cell Death / immunology
  • Gene Expression
  • Signal Transduction / physiology
  • T-Lymphocytes / ultrastructure