How alpha beta T-cell receptors 'see' peptide/MHC complexes

Immunol Today. 1993 Dec;14(12):597-602. doi: 10.1016/0167-5699(93)90199-u.


Recent results have added new information to our understanding of alpha beta T-cell receptor mediated recognition. In particular, we find that the V(D)J junction or 'CDR3' portion of TCR alpha and beta seem most important in contacting peptides bound to MHC molecules, consistent with previous predictions. Surprisingly, these same CDR3-peptide contacts also appear to have a major influence on the TCR-MHC molecule interactions as well.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cytochrome c Group / genetics
  • Cytochrome c Group / immunology
  • Hybridomas
  • Immunoglobulin Variable Region / immunology*
  • Major Histocompatibility Complex / immunology*
  • Molecular Sequence Data
  • Moths / enzymology
  • Peptides / immunology*
  • Receptors, Antigen, T-Cell, alpha-beta / immunology*
  • T-Lymphocytes / immunology


  • Cytochrome c Group
  • Immunoglobulin Variable Region
  • Peptides
  • Receptors, Antigen, T-Cell, alpha-beta