Abstract
The safety profile of a new controlled-titer feline panleukopenia-rhinotracheitis-calicivirus-Chlamydia psittaci vaccine was compared to that of a currently-marketed vaccine. Of particular interest were delayed reactions (previously unreported in the literature in felines) occurring 7 to 21 days after vaccination, and the effect of concurrent vaccinations and cat age on the delayed reaction rate. Nineteen hundred twenty-four doses of the new vaccine and 364 doses of the comparison vaccine were administered in 42 participating veterinary practices. The postvaccination evaluation period was 21 days. Reactions (anaphylaxis, short- and long-term lethargy, inappetence, pain, upper respiratory inflammation, delayed fever, anorexia, and miscellaneous events) were reported in 3.33% of cats receiving the controlled-titer vaccine and in 3.02% of cats receiving the comparison vaccine. The difference was not statistically significant (P = 0.45). Reaction rate of the controlled-titer vaccine and that of the vaccine currently accepted by veterinarians appear to be equivalent.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Age Factors
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Anaphylaxis / chemically induced
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Anaphylaxis / veterinary
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Animals
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Bacterial Vaccines / adverse effects*
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Bacterial Vaccines / immunology
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Caliciviridae Infections / prevention & control
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Caliciviridae Infections / veterinary
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Calicivirus, Feline / immunology*
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Cat Diseases / prevention & control
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Cats
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Chlamydophila psittaci / immunology*
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Feline Panleukopenia / prevention & control
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Feline Panleukopenia Virus / immunology*
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Female
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Herpesviridae / immunology*
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Herpesviridae Infections / prevention & control
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Herpesviridae Infections / veterinary
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Hypersensitivity, Delayed / chemically induced
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Hypersensitivity, Delayed / veterinary
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Male
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Psittacosis / prevention & control
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Psittacosis / veterinary
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Vaccination / adverse effects
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Vaccination / veterinary
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Vaccines, Attenuated / adverse effects
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Vaccines, Attenuated / immunology
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Vaccines, Combined / adverse effects
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Vaccines, Combined / immunology
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Viral Vaccines / adverse effects*
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Viral Vaccines / immunology
Substances
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Bacterial Vaccines
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Vaccines, Attenuated
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Vaccines, Combined
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Viral Vaccines