[Planning of samples for linkage analysis. Incomplete penetrance]

Genetika. 1993 Oct;29(10):1741-9.
[Article in Russian]


Dependence of the minimal size of a pedigree sample providing the given quality of a linkage decision on the genotype penetrance of the localized gene is considered. The two ways of the sample informativity increase are discussed and their effects are estimated. These ways are: the adequate choice of a marker gene and certain complication of a pedigree structure. It is shown for the latter that the effect can be achieved only for certain phenotypic characteristics of the additional pedigree members.

Publication types

  • English Abstract

MeSH terms

  • Chromosome Mapping
  • Genetic Linkage*
  • Genetics, Population*
  • Genotype
  • Humans
  • Pedigree
  • Sampling Studies