The gene for murine CTP:phosphocholine cytidylyltransferase (Ctpct) is located on mouse chromosome 16

Genomics. 1993 Dec;18(3):698-701. doi: 10.1016/s0888-7543(05)80377-5.


CTP:phosphocholine cytidylyltransferase is the rate-controlling enzyme in phosphatidylcholine biosynthesis and is essential for the survival of eukaryotic cells. The murine cDNA for the cytidylyltransferase was cloned and sequenced. A genomic clone was isolated and the chromosomal location of the Ctpct locus determined by Southern blot hybridization of DNAs from a panel of interspecific backcross progeny derived from matings of [(C57BL/6J x Mus spretus)F1 x C57BL/6J] mice. These data place the Ctpct gene on mouse chromosome 16 between the Smst and Stf-1 genes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Choline-Phosphate Cytidylyltransferase
  • Chromosome Mapping*
  • Crosses, Genetic
  • Female
  • Genomic Library
  • Male
  • Mice
  • Mice, Inbred C57BL / genetics*
  • Molecular Sequence Data
  • Muridae / genetics*
  • Nucleotidyltransferases / genetics*
  • Polymerase Chain Reaction
  • Restriction Mapping
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae / genetics
  • Sequence Homology, Amino Acid


  • Nucleotidyltransferases
  • Choline-Phosphate Cytidylyltransferase

Associated data

  • GENBANK/Z12302