A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region

Genomics. 1993 Dec;18(3):709-11. doi: 10.1016/s0888-7543(05)80380-5.


A novel human gene (sazD) that maps to the autosomal dominant polycystic kidney disease region shares sequence similarity with members of the beta-transducin superfamily. The cDNA sazD-c predicts an approximately 58-kDa protein (sazD) with seven internal repeats, similar to the WD-40 motif of the transducin family. The size of this protein family has been expanding rapidly; however, neither the structure nor the function of this repeated motif is known. Preliminary data do not suggest that sazD is mutated in patients with polycystic kidney disease.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Base Sequence
  • Chromosome Mapping
  • Consensus Sequence
  • Humans
  • Kidney / metabolism
  • Molecular Sequence Data
  • Multigene Family*
  • Mutation
  • Polycystic Kidney, Autosomal Dominant / genetics*
  • Repetitive Sequences, Nucleic Acid
  • Sequence Homology, Amino Acid
  • Transducin / genetics*


  • Transducin

Associated data

  • GENBANK/U02609