Magnetic resonance evaluation of disease activity during pregnancy in multiple sclerosis

Neurology. 1994 Feb;44(2):327-9. doi: 10.1212/wnl.44.2.327.


We followed two women with MS during pregnancy by means of serial unenhanced MR imaging. On each follow-up image, we assessed the number of new or enlarging lesions. Both women showed a decrease in MR disease activity during the second half of pregnancy and a return of MR disease activity to prepregnancy levels in the first months postpartum. These findings support the view that pregnancy reduces disease activity in MS.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain / pathology*
  • Contrast Media
  • Female
  • Follow-Up Studies
  • Gadolinium
  • Gadolinium DTPA
  • Humans
  • Infant, Newborn
  • Magnetic Resonance Imaging*
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis / physiopathology*
  • Organometallic Compounds
  • Pentetic Acid / analogs & derivatives
  • Pregnancy
  • Pregnancy Complications / diagnosis
  • Pregnancy Complications / physiopathology*
  • Pregnancy Trimester, First
  • Pregnancy Trimester, Second
  • Puerperal Disorders / diagnosis
  • Puerperal Disorders / physiopathology


  • Contrast Media
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA