Frequency of synchronous oscillations of neuronal activity increases during development and is correlated to the number of synapses in cultured cortical neuron networks

Neurosci Lett. 1993 Dec 12;163(2):163-5. doi: 10.1016/0304-3940(93)90372-r.

Abstract

It has been proposed that synchronous oscillations of groups of neurons corresponding to sensory information and changes in temporal pattern of oscillations are important for processing of the information in the cortex. However, it has not been determined yet how the temporal or spatial pattern of such oscillations are regulated. We observed spontaneous synchronous oscillations of Ca2+ transients, which were caused by bursts of action potentials of neurons, even in cultured cortical neurons. The frequency of synchronous Ca2+ oscillations increased with development of synapses in cultured neurons and was highly correlated to the number of synapses formed in the same culture.

MeSH terms

  • Animals
  • Calcium / metabolism
  • Cell Division
  • Cells, Cultured
  • Cellular Senescence
  • Cerebral Cortex / physiology*
  • Fetus
  • Fura-2
  • Nerve Net / physiology*
  • Neurons / cytology
  • Neurons / physiology*
  • Oscillometry
  • Rats
  • Synapses / physiology*
  • Synapses / ultrastructure
  • Time Factors

Substances

  • Calcium
  • Fura-2