Is age-related maculopathy associated with cataracts?

Arch Ophthalmol. 1994 Feb;112(2):191-6. doi: 10.1001/archopht.1994.01090140067025.


Objective: To evaluate the relationship between three types of cataract or cataract surgery and age-related maculopathy.

Design: Population-based prevalence study.

Participants: A total of 4926 people participating in The Beaver Dam Eye Study from 1988 through 1990.

Main outcome measures: Grading of photographs for nuclear sclerosis, cortical cataract, and posterior subcapsular cataract and signs of age-related maculopathy was performed using standardized protocols.

Results: After adjusting for other risk factors, nuclear sclerosis was associated with increased odds of early age-related maculopathy (odds ratio [OR], 1.96; 95% confidence interval [CI], 1.28 to 3.01) but not of late age-related maculopathy (OR, 1.38; 95% CI, 0.52 to 3.63). Neither cortical nor posterior subcapsular cataracts were related to age-related maculopathy. There were increased odds of early age-related maculopathy in eyes that had undergone cataract surgery.

Conclusion: These data suggest a possible commonly shared pathogenesis between nuclear sclerotic cataract and age-related maculopathy.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Cataract / complications*
  • Cataract / etiology
  • Cataract Extraction
  • Female
  • Humans
  • Lens Nucleus, Crystalline / pathology
  • Macula Lutea
  • Macular Degeneration / complications*
  • Macular Degeneration / etiology
  • Male
  • Middle Aged
  • Odds Ratio
  • Prevalence
  • Retinal Drusen / complications*
  • Retinal Drusen / etiology
  • Risk Factors