Proteolytic enzyme activity of blood leukocytes and cerebrospinal fluid in multiple sclerosis

Ann Neurol. 1978 Oct;4(4):337-44. doi: 10.1002/ana.410040409.


Upon stimulation by immune complexes, the polymorphonuclear (PMN) blood secretes lysosomal hydrolases, including neutral proteinase, which is concentrated in the PMN cell. Neutral and acid proteinase activity were increased and decreased, respectively, in the circulating white cells of patients with multiple sclerosis during an exacerbation of the disease, but there was no correlation with serum immune complex levels. Neutral proteolytic activity in the cellular fraction of the cerebrospinal fluid was also found to be elevated in acute multiple sclerosis, as monitored by digestion of myelin basic protein.

MeSH terms

  • Antigen-Antibody Complex
  • Granulocytes / enzymology*
  • Humans
  • Hydrogen-Ion Concentration
  • Multiple Sclerosis / enzymology*
  • Myelin Basic Protein
  • Peptide Hydrolases / analysis*
  • Peptide Hydrolases / blood
  • Peptide Hydrolases / cerebrospinal fluid


  • Antigen-Antibody Complex
  • Myelin Basic Protein
  • Peptide Hydrolases