Aldosterone and sodium HOMEOSTASIS in preterm infants

Acta Paediatr Scand. 1977 Jan;66(1):103-9. doi: 10.1111/j.1651-2227.1977.tb07815.x.


A specific mass spectrometric method was used for tetrahydroaldosterone determination in urine of preterm infants (26-34 weeks gestational age) up to 9 weeks of age. Hyponatraemia during the first 2 weeks of life was associated with an excretion of tetrahydroaldosterone (5-50 mug/24 h) comparable with full-term infants. Excretion of tetrahydroaldosterone was significantly elevated in all infants studied during the third week of life (80-350 mug/24 h) and this was associated with establishment of positive sodium balance. The excretion of tetrahydro aldosterone remained high for 2 or 3 weeks. The results are discussed in relation to the development of renal tubules and control mechanism for sodium homeostasis.

MeSH terms

  • Aldosterone / analogs & derivatives*
  • Aldosterone / urine
  • Female
  • Homeostasis*
  • Humans
  • Infant, Newborn
  • Infant, Premature*
  • Male
  • Mass Spectrometry
  • Natriuresis
  • Sodium / blood
  • Sodium / urine*


  • Aldosterone
  • Sodium