Abstract
The complete amino acid sequence of an invertebrate calcium channel alpha 1-subunit from housefly (Musca domestica) larvae (designated Mdl alpha 1) has been deduced by cDNA cloning and sequence analysis. Mdl alpha 1 shares higher percent sequence identity with 1,4-dihydropyridine (DHP)-sensitive L-type than with DHP-insensitive calcium channels. As shown by whole mount in situ hybridization and immunostaining Mdl alpha 1 is predominantly expressed in the larval body wall musculature.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Calcium Channels / genetics*
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Cloning, Molecular*
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DNA, Complementary / chemistry
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DNA, Complementary / genetics
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Dihydropyridines / pharmacology
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Gene Expression
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Houseflies / chemistry*
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Houseflies / genetics
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In Situ Hybridization
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Larva / metabolism
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Molecular Sequence Data
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Muscles / metabolism
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RNA, Messenger / analysis
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RNA, Messenger / metabolism
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Sequence Analysis
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Sequence Homology
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Tissue Distribution
Substances
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Calcium Channels
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DNA, Complementary
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Dihydropyridines
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RNA, Messenger
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1,4-dihydropyridine