Sequential imputation and multipoint linkage analysis

Genet Epidemiol. 1993;10(6):483-8. doi: 10.1002/gepi.1370100626.


A novel Monte Carlo method for linkage analyses involving large pedigrees and many polymorphic loci is introduced. Issues related to the efficiency of the method are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping
  • Genetic Diseases, Inborn / genetics
  • Genetic Linkage*
  • Genetic Markers
  • Humans
  • Monte Carlo Method*
  • Pedigree


  • Genetic Markers