Effect of ignoring genotype-environment interaction on segregation analysis of quantitative traits

Genet Epidemiol. 1993;10(6):581-6. doi: 10.1002/gepi.1370100642.


Thirty replicates of 200 nuclear families (6 members each) were generated under three GxE interaction models. Segregation analyses of these data were performed using a regressive model taking into account an interaction effect or not. Results showed that ignoring the GxE interaction markedly decreased the power for accepting a major gene and led to serious bias in parameter estimates.

MeSH terms

  • Adult
  • Child, Preschool
  • Coronary Disease / genetics*
  • Environment*
  • Female
  • Gene Expression
  • Genetic Predisposition to Disease*
  • Genotype*
  • Humans
  • Male
  • Models, Genetic*
  • Monte Carlo Method
  • Regression Analysis