Mild to moderate zinc deficiency in short children: effect of zinc supplementation on linear growth velocity

J Pediatr. 1993 Jul;123(1):65-9. doi: 10.1016/s0022-3476(05)81538-0.

Abstract

Twenty-one prepubertal, short Japanese children (11 boys) without endocrine abnormalities were identified as having mild-to-moderate zinc deficiency by zinc kinetics studies (zinc body clearance > or = 20 ml/kg per hour). Only one child had a serum zinc level < 65 micrograms/dl (cutoff level). A total of 10 children (5 boys) received 5 mg/kg per day of zinc sulfate for 6 months; 11 untreated children (6 boys) served as control subjects. During treatment, calorie intake (p < 0.01), growth velocity (p < 0.01), serum zinc, calcium, and phosphorus concentrations, alkaline phosphatase activity (p < 0.001), percentage of tubular reabsorption of phosphorus (p < 0.05), ratio of maximal tubular reabsorption rate for phosphorus to the glomerular filtration rate (p < 0.05), serum osteocalcin level (p < 0.01), and plasma insulin-like growth factor 1 (p < 0.05) were significantly increased, but urinary excretion of growth hormone was unchanged in the zinc-supplemented group. All these values were unchanged in the untreated children. We conclude that zinc supplementation is effective for inducing growth in short children with zinc deficiency, and that body zinc clearance tests facilitate detection of marginal zinc deficiency.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Body Height / drug effects*
  • Child
  • Child, Preschool
  • Female
  • Growth / drug effects*
  • Growth Hormone / blood
  • Growth Hormone / drug effects
  • Growth Hormone / metabolism
  • Humans
  • Male
  • Metabolic Clearance Rate
  • Sulfates / administration & dosage*
  • Sulfates / pharmacokinetics
  • Zinc / administration & dosage*
  • Zinc / blood
  • Zinc / deficiency*
  • Zinc / pharmacokinetics
  • Zinc Sulfate

Substances

  • Sulfates
  • Zinc Sulfate
  • Growth Hormone
  • Zinc