Familial polyposis

Cancer. 1977 Jan;39(1):267-73. doi: 10.1002/1097-0142(197701)39:1<267::aid-cncr2820390141>3.0.co;2-x.


Familial polyposis is a genetically-transmitted disease characterized by multiple adenomatous colorectal polyps and a high risk for development of adenocarcinoma. Familial polyposis and Gardner's syndrome should be differentiated from other penetically-linked polyposis syndromes lacking a predisposition for cancer. Total colectomy and ileorectal anastomosis, aggressive follow-up and intensive surveillance of non-polyp bearing relatives can reduce the risk of developing cancer. From an epidemiologic point of veiw, polyposis is a valuable model for the study of the interaction of genetic and environmental factors in the genesis of colon cancer.

MeSH terms

  • Adult
  • Age Factors
  • Colonic Neoplasms / diagnosis
  • Colonic Neoplasms / genetics*
  • Colonic Neoplasms / surgery
  • Environment
  • Family Characteristics
  • Humans
  • Intestinal Polyps / diagnosis
  • Intestinal Polyps / genetics*
  • Intestinal Polyps / surgery
  • Neoplasm Regression, Spontaneous
  • Phenotype
  • Rectal Neoplasms / diagnosis
  • Rectal Neoplasms / genetics*
  • Rectal Neoplasms / surgery
  • Risk
  • Syndrome