Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization

Vaccine. 1993;11(6):637-42. doi: 10.1016/0264-410x(93)90309-l.


Helicobacter pylori infection of human gastric epithelium has been associated with gastritis, ulcers and gastric cancers. In an H. felis, germ-free mouse model of infection, oral immunization with bacterial antigens plus cholera toxin resulted in elevated serum, gastric and intestinal anti-H. felis antibody titres and protection from acute infection. Mice given monoclonal IgA anti-H. felis antibody at the time of initial challenge were also protected from infection. These results demonstrate that oral vaccination may be a feasible approach for the prevention of H. pylori infection of humans.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Animals
  • Antibodies, Bacterial / biosynthesis*
  • Antigens, Bacterial / administration & dosage
  • Antigens, Bacterial / immunology
  • Bacterial Vaccines* / administration & dosage
  • Bacterial Vaccines* / immunology
  • Disease Models, Animal
  • Enzyme-Linked Immunosorbent Assay
  • Helicobacter / immunology*
  • Helicobacter Infections / prevention & control*
  • Immunization, Passive*
  • Immunoglobulin A / immunology*
  • Mice
  • Vaccination*


  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Vaccines
  • Immunoglobulin A