Proteoglycan fragments in rabbit joint fluid correlated to arthrosis stage

Acta Orthop Scand. 1993 Jun;64(3):312-6. doi: 10.3109/17453679308993633.


Proteoglycan fragment concentrations in joint fluid of rabbit knees with various degrees of secondary arthrosis after meniscal resection, meniscal substitution, and anterior cruciate ligament transection, were related to the gross appearance of the articular cartilage. Knees with normal cartilage were distinguishable by the concentration of proteoglycan fragments in joint fluid from knees with arthrosis. We found a correlation (r 0.61) between increasing arthrosis and increasing concentrations of proteoglycan fragments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arthritis / metabolism
  • Arthritis / pathology*
  • Knee Joint*
  • Proteoglycans / analysis*
  • Rabbits
  • Sensitivity and Specificity
  • Synovial Fluid / chemistry*


  • Proteoglycans