Preventing restenosis with fish oils following coronary angioplasty. A meta-analysis

Arch Intern Med. 1993 Jul 12;153(13):1595-601.


Background: No medical therapy has been shown to reduce the rate of restenosis following percutaneous transluminal coronary angioplasty. We examined the existing evidence for the use of omega-3 fatty acids in this capacity with the tool of meta-analysis.

Methods: A computerized search and a bibliographic review of published articles were performed. Abstracts were identified through journals, Index Medicus, and an unpublished listing of recent requests for fish oil for experimental use. All English-language randomized clinical trials with available reports were included in the analysis. The quality, design differences, and outcomes were evaluated for each study.

Results: For four studies that used angiography to define coronary restenosis, the absolute difference in restenosis rates between treatment and control groups was 13.9% (95% confidence interval [CI], 3.2% to 24.5%). Furthermore, regression analysis revealed a positive linear relationship between the dose of omega-3 fatty acids used and the absolute difference in restenosis rates (r = .99, P < .03). When three studies that used stress testing as a means of determining restenosis rates were added to the four studies that used angiography, the risk difference was 5.1% (95% CI, -3.8% to 13.9%).

Conclusions: Restenosis after coronary angioplasty is reduced by supplemental fish oils, and the extent of the observed benefit may be dependent on the dose of omega-3 fatty acids used.

Publication types

  • Meta-Analysis

MeSH terms

  • Angioplasty, Balloon, Coronary*
  • Coronary Disease / diet therapy*
  • Coronary Disease / prevention & control*
  • Fatty Acids, Omega-3 / therapeutic use
  • Fish Oils / therapeutic use*
  • Humans
  • Randomized Controlled Trials as Topic
  • Recurrence
  • Regression Analysis


  • Fatty Acids, Omega-3
  • Fish Oils