Genetics of resistance of Bacteroides species to 5-nitroimidazole

Clin Infect Dis. 1993 Jun:16 Suppl 4:S401-3. doi: 10.1093/clinids/16.supplement_4.s401.

Abstract

Thirty-three clinical isolates of Bacteroides strains with a moderate-to-high level of resistance to 5-nitroimidazole were compared with three strains previously studied by Southern blotting of their DNA. Whether plasmid-borne or chromosomally determined, all genetic determinants that are resistant to 5-nitroimidazole belong to two hybridization groups.

Publication types

  • Comparative Study

MeSH terms

  • Bacteroides / drug effects*
  • Bacteroides / genetics
  • Bacteroides / isolation & purification
  • Bacteroides Infections / drug therapy
  • Bacteroides Infections / microbiology
  • Chromosomes, Bacterial
  • Cloning, Molecular
  • Conjugation, Genetic
  • Drug Resistance, Microbial / genetics
  • Genes, Bacterial
  • Humans
  • In Vitro Techniques
  • Nitroimidazoles / pharmacology*
  • R Factors

Substances

  • Nitroimidazoles
  • 4-nitroimidazole