Isoniazid induced encephalopathy in dialysis patients

Tuber Lung Dis. 1993 Apr;74(2):136-9. doi: 10.1016/0962-8479(93)90042-V.


Three dialysis patients with extrapulmonary tuberculosis developed confusion 4-14 days after commencement of treatment with anti-tuberculosis drugs, despite the use of prophylactic pyridoxine. Full recovery of conscious state resulted within 1 week in all patients after stopping isoniazid. In 2 patients confusion recurred on rechallenge of the drug. The risk factors of isoniazid induced encephalopathy and the dosage of isoniazid in uraemic patients were discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Confusion / chemically induced*
  • Confusion / prevention & control
  • Female
  • Humans
  • Isoniazid / adverse effects*
  • Kidney Failure, Chronic / complications
  • Middle Aged
  • Pyridoxine / therapeutic use
  • Renal Dialysis*
  • Tuberculosis / complications


  • Pyridoxine
  • Isoniazid