Effect of Cordyceps sinensis on erythropoiesis in mouse bone marrow

Chin Med J (Engl). 1993 Apr;106(4):313-6.


The effect of Cordyceps sinensis crystal (CS-Cr) on stimulating proliferation of erythroid progenitor cells (CFU-E and BFU-E) in LACA mouse marrow in vivo and in vitro by methyl cellulose gel culture system is reported. The numbers of CFU-E and BFU-E were increased after 5 consecutive daily treatment with 100, 150 and 200 mg/kg of CS-Cr with a peak at 150 mg/kg. Higher doses (> 150 mg/kg) of CS-Cr resulted in a reduction of the peak of CFU-E and BFU-E and then, the numbers returned to the control level with increased doses. The cytosine arabinoside (Ara-C) suicide test showed significant increases in the percentage of CFU-E and BFU-E in S-phase after CS-Cr treatment. Pretreatment of mice with CS-Cr could protect CFU-E and BFU-E against the cytotoxic agent--harringtonine. Addition of CS-Cr to culture system also promoted the generation of CFU-E and BFU-E at concentrations of 150-200 micrograms/ml in vitro. With a liquid culture technique, a stimulatory action of CS-Cr on fibroblast colony-forming units (CFU-F) proliferation was seen in vivo and in vitro.

MeSH terms

  • Animals
  • Ascomycota
  • Bone Marrow Cells
  • Cell Division / drug effects
  • Drugs, Chinese Herbal / pharmacology*
  • Erythroid Precursor Cells / cytology
  • Erythroid Precursor Cells / drug effects*
  • Erythropoiesis / drug effects*
  • Fibroblasts / drug effects
  • Harringtonines / adverse effects
  • Hypocreales
  • Lepidoptera
  • Male
  • Mice
  • Stem Cells / drug effects


  • Drugs, Chinese Herbal
  • Harringtonines