Abstract
This study was designed to assess the efficacy of oral nifedipine as compared to oral isosorbide-5-mononitrate in the prevention of spontaneous and induced vasospastic myocardial ischaemia. Twenty-one patients admitted to the Coronary Care Unit as a result of angina at rest underwent both Holter monitoring and an echo-ergonovine test during placebo and following either isosorbide-5-mononitrate or nifedipine according to a double-blind randomized trial. Both drugs caused a statistically significant reduction in spontaneous (87% and 95%, respectively) and induced ischaemic attacks (66% and 75%, respectively). No significant difference was found between the two drugs.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Administration, Oral
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Adult
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Angina Pectoris, Variant / diagnostic imaging
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Angina Pectoris, Variant / drug therapy
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Double-Blind Method
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Echocardiography
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Electrocardiography / drug effects
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Electrocardiography, Ambulatory / drug effects
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Ergonovine*
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Exercise Test / drug effects
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Female
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Humans
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Isosorbide Dinitrate / analogs & derivatives*
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Isosorbide Dinitrate / therapeutic use
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Male
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Middle Aged
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Myocardial Ischemia / diagnostic imaging
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Myocardial Ischemia / drug therapy*
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Nifedipine / therapeutic use*
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Vasodilator Agents / therapeutic use*
Substances
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Vasodilator Agents
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Nifedipine
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Isosorbide Dinitrate
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isosorbide-5-mononitrate
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Ergonovine