Efficacy of isosorbide-5-mononitrate versus nifedipine in preventing spontaneous and ergonovine-induced myocardial ischaemia. A double-blind, placebo-controlled study

Eur Heart J. 1993 Jun;14(6):845-51. doi: 10.1093/eurheartj/14.6.845.


This study was designed to assess the efficacy of oral nifedipine as compared to oral isosorbide-5-mononitrate in the prevention of spontaneous and induced vasospastic myocardial ischaemia. Twenty-one patients admitted to the Coronary Care Unit as a result of angina at rest underwent both Holter monitoring and an echo-ergonovine test during placebo and following either isosorbide-5-mononitrate or nifedipine according to a double-blind randomized trial. Both drugs caused a statistically significant reduction in spontaneous (87% and 95%, respectively) and induced ischaemic attacks (66% and 75%, respectively). No significant difference was found between the two drugs.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Angina Pectoris, Variant / diagnostic imaging
  • Angina Pectoris, Variant / drug therapy
  • Double-Blind Method
  • Echocardiography
  • Electrocardiography / drug effects
  • Electrocardiography, Ambulatory / drug effects
  • Ergonovine*
  • Exercise Test / drug effects
  • Female
  • Humans
  • Isosorbide Dinitrate / analogs & derivatives*
  • Isosorbide Dinitrate / therapeutic use
  • Male
  • Middle Aged
  • Myocardial Ischemia / diagnostic imaging
  • Myocardial Ischemia / drug therapy*
  • Nifedipine / therapeutic use*
  • Vasodilator Agents / therapeutic use*


  • Vasodilator Agents
  • Nifedipine
  • Isosorbide Dinitrate
  • isosorbide-5-mononitrate
  • Ergonovine