MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme

FEBS Lett. 1993 Jul 12;326(1-3):171-6. doi: 10.1016/0014-5793(93)81785-x.


We have isolated a novel mouse gene, MFH-1 (mesenchyme fork head 1) that is related to the Drosophila fork head and rat HNF3 genes. MFH-1 encodes a distinct fork head domain that is classified into a distinct subfamily. A recombinant MFH-1 protein could bind to the HNF3 binding site. MFH-1 is expressed temporally in developing embryos, first in the non-notochordal mesoderm and later in areas of mesenchymal condensation in the trunk, head, and limbs. Our results suggest that MFH-1 might be involved in the formation of special mesenchymal tissues.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / metabolism
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics*
  • Drosophila
  • Embryo, Mammalian / metabolism
  • Embryo, Nonmammalian
  • Embryonic and Fetal Development
  • Forkhead Transcription Factors
  • Gene Expression*
  • Hepatocyte Nuclear Factor 3-alpha
  • Hepatocyte Nuclear Factor 3-beta
  • Hepatocyte Nuclear Factor 3-gamma
  • Mesoderm / metabolism*
  • Mice
  • Molecular Sequence Data
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / genetics
  • Polymerase Chain Reaction
  • RNA, Messenger / analysis
  • Rats
  • Sequence Homology
  • Transcription Factors / chemistry
  • Transcription Factors / genetics*


  • DNA-Binding Proteins
  • Forkhead Transcription Factors
  • Foxa1 protein, mouse
  • Foxa1 protein, rat
  • Foxa2 protein, mouse
  • Foxa2 protein, rat
  • Foxa3 protein, mouse
  • Foxa3 protein, rat
  • Hepatocyte Nuclear Factor 3-alpha
  • Nuclear Proteins
  • RNA, Messenger
  • Transcription Factors
  • mesenchyme fork head 1 protein
  • Hepatocyte Nuclear Factor 3-gamma
  • Hepatocyte Nuclear Factor 3-beta