Clinical and electrophysiological study of the peripheral nervous system in the elderly

J Neurol. 1993 May;240(5):263-8. doi: 10.1007/BF00838158.


The effect of age on the peripheral nervous system was investigated by clinical examination and neurophysiological studies in 59 subjects aged 60-103 years and 23 young subjects. A full laboratory screen for factors which, though clinically silent, may constitute risk factors (RFs) for peripheral neuropathy was also performed in the elderly subjects. Our findings show that the presence of RFs affects exceptionally the electrophysiological parameters in a statistically significant way. The age-dependent changes in nerve conduction parameters were well predicted by non-linear models. The simultaneous electromyographical study demonstrates the re-innervation capacity of the motor system.

Publication types

  • Comparative Study

MeSH terms

  • Action Potentials
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Electromyography
  • Humans
  • Hypesthesia / physiopathology*
  • Middle Aged
  • Neural Conduction
  • Peripheral Nerves / physiopathology*
  • Reflex, Abnormal / physiology*
  • Reflex, Stretch / physiology*
  • Risk Factors
  • Vibration*