Regression of metastatic renal cell carcinoma after cytoreductive nephrectomy

J Urol. 1993 Aug;150(2 Pt 1):463-6. doi: 10.1016/s0022-5347(17)35514-3.


Fewer than 1% of patients with renal cell carcinoma are reported to experience spontaneous regression of metastatic lesions after nephrectomy. We report on 4 of 91 patients (4.4%) with metastatic renal cell carcinoma who had spontaneous regression of all metastatic lesions after cytoreductive nephrectomy. These patients were carefully selected before surgery for the ability to receive high dose interleukin-2. One patient had recurrence at 2 months, 1 had recurrence at 11 months, and 2 had no evidence of disease at 3 and 4.5 years.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Renal Cell / pathology
  • Carcinoma, Renal Cell / secondary*
  • Carcinoma, Renal Cell / surgery*
  • Female
  • Humans
  • Kidney Neoplasms / pathology
  • Kidney Neoplasms / surgery*
  • Male
  • Middle Aged
  • Neoplasm Regression, Spontaneous
  • Nephrectomy*