Main indication for extracorporeal membrane oxygenation (ECMO) is respiratory failure in the newborn. Less frequently ECMO is used for cardiac support. We report on a 4 months old boy, who suddenly fell ill with an acute viral myocarditis and heart failure (left-ventricular shortening fraction lowered to 17%). After failure of conventional management and resuscitation (twice) due to asystolic, veno-arterial ECMO was installed for a total time of 4 days. Under ECMO there was complete recovery of left-ventricular function; the infant was discharged 1 month after admission to hospital. ECMO-therapy should not only be considered in children with respiratory failure, but also in those with potentially reversible cardiac failure.