Supraophthalmic chemotherapy with long tapered catheter: distribution evaluated with intraarterial and intravenous Tc-99m HMPAO

Radiology. 1993 Aug;188(2):347-50. doi: 10.1148/radiology.188.2.8327676.


Supraophthalmic intraarterial chemotherapy has not become popular due to a high incidence of damage to the normal brain and eye. This damage is due to inhomogeneous distribution of the agent secondary to streaming and other flow-related phenomena. To try to minimize this complication, the authors developed a catheter and studied different infusion techniques. A 4.5-F catheter tapered to 2.5 F was used to perform supraophthalmic intraarterial chemotherapy in 26 patients with malignant gliomas. Forty-one of 45 catheterizations were successful. In 17 patients (20 procedures), technetium-99m hexamethyl-propyleneamine oxime (HMPAO) was then injected through the catheter and single photon emission computed tomography was performed to assess the cerebral distribution of the radiopharmaceutical with either a pulsatile or continuous infusion technique. Diffuse and relatively homogeneous distribution of Tc-99m HMPAO was observed with fast pulsatile infusion (10 of 10 procedures); however, inhomogeneous distribution was mostly seen with slow continuous infusion (eight of 10 procedures).

MeSH terms

  • Adolescent
  • Adult
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / drug therapy*
  • Catheterization*
  • Child
  • Glioma / diagnostic imaging*
  • Glioma / drug therapy*
  • Humans
  • Infusions, Intra-Arterial
  • Infusions, Intravenous
  • Middle Aged
  • Organotechnetium Compounds / administration & dosage*
  • Oximes / administration & dosage*
  • Radionuclide Imaging
  • Technetium Tc 99m Exametazime


  • Organotechnetium Compounds
  • Oximes
  • Technetium Tc 99m Exametazime