Does decreased skeletal uptake of 99mTc-methylene bisphosphonate in irradiated bone indicate the absence of bone metastases?

Radiother Oncol. 1993 Apr;27(1):63-5. doi: 10.1016/0167-8140(93)90046-b.

Abstract

Reduced uptake of 99mTc-methylene bisphosphonate (99mTc-MBP) was found in irradiated bone in all of 13 tumour-free patients who had undergone radiotherapy (30-40 Gy) due to seminoma 3-8 years prior to bone scintigraphy. Decreased uptake of 99mTc phosphate compounds can not per se be interpreted as a sign of absence of metastases or reduced tumour burden.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetabulum / diagnostic imaging
  • Acetabulum / metabolism
  • Acetabulum / radiation effects
  • Adult
  • Aorta
  • Dysgerminoma / radiotherapy*
  • Humans
  • Lumbar Vertebrae / diagnostic imaging
  • Lumbar Vertebrae / metabolism*
  • Lumbar Vertebrae / radiation effects*
  • Lymph Nodes / diagnostic imaging
  • Lymph Nodes / metabolism
  • Lymph Nodes / radiation effects
  • Middle Aged
  • Radionuclide Imaging
  • Spinal Neoplasms / diagnostic imaging*
  • Spinal Neoplasms / secondary*
  • Technetium Tc 99m Medronate / pharmacokinetics*
  • Thoracic Vertebrae / diagnostic imaging
  • Thoracic Vertebrae / metabolism*
  • Thoracic Vertebrae / radiation effects*

Substances

  • Technetium Tc 99m Medronate