Gene elav of Drosophila melanogaster: a prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humans

J Neurobiol. 1993 Jun;24(6):723-39. doi: 10.1002/neu.480240604.


Regulated gene activity is crucial to the formation and function of the nervous system. It is well known that gene regulation can occur at the transcriptional, post-transcriptional, translational, and post-translational levels. In this review our focus has been on the post-transcriptional regulation in neurons and on neural-specific RNA binding proteins that may be involved in post-transcriptional modulation of gene activity. We have taken advantage of this opportunity to review our work on the elav gene of Drosophila melanogaster which encodes a neural-specific RNA binding protein and relate it to other members of this elav-like gene family. We report new data that suggests that elav is post-transcriptionally regulated and we demonstrate that below-threshold levels of ELAV protein severely affects neuronal differentiation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Drosophila melanogaster / genetics*
  • Gene Expression Regulation
  • Humans
  • Multigene Family*
  • Mutation
  • Nerve Tissue Proteins / genetics*
  • Neurons / metabolism
  • RNA, Messenger / genetics
  • RNA-Binding Proteins / genetics*


  • Nerve Tissue Proteins
  • RNA, Messenger
  • RNA-Binding Proteins