The effect of dopamine infusion on insulin and glucagon secretion in man

J Clin Endocrinol Metab. 1977 Jan;44(1):196-8. doi: 10.1210/jcem-44-1-196.


The effect of dopamine on the release of insulin and glucagon was investigated in eight adult subjects. Dopamine infused iv at a rate of 4 mug/kg/min X 2 hr, unaccompanied by cardiovascular changes, induced a prompt and significant increase in plasma insulin and glucagon and in plasma glucose levels. These findings suggest that dopamine may stimulate both alpha and beta cells.

MeSH terms

  • Adult
  • Blood Glucose / metabolism*
  • Dopamine / pharmacology*
  • Eating
  • Female
  • Glucagon / blood*
  • Humans
  • Insulin / blood*
  • Male


  • Blood Glucose
  • Insulin
  • Glucagon
  • Dopamine