Authors, studying in patients with RDC-endogenous major depression and distinct quality of depressed mood, using a Factor Analysis and two Stepwise Multiple Regression Analysis with data: 17 items of the Hamilton Rating Scale for Depression, its total score, age, number of episode, presence/absence of life events, Newcastle Index, EPI-Extroversion and EPI-Neuroticism. In the sample two profiles are found, in agreement with topics for "neurotic" and "endogenous" depression. More "neurotic" subject suffering the first episode, and more "endogenous" the others. Authors believe confirmed their hypothesis: that classification show the same illness in two different evolutive moments.