Bacterial vaginosis and prematurity in Indonesia: association in early and late pregnancy

Am J Obstet Gynecol. 1993 Jul;169(1):175-8. doi: 10.1016/0002-9378(93)90157-e.


Objective: Our objective was to examine the association between preterm delivery and bacterial vaginosis in early and late pregnancy.

Study design: We evaluated 490 pregnant women at three hospitals in Jakarta, Indonesia, for bacterial vaginosis at 16 to 20 weeks' and 28 to 32 weeks' gestation and observed them through delivery.

Results: We found significant associations between preterm delivery (gestational age < 37 weeks) and bacterial vaginosis diagnosed at 16 to 20 weeks' gestation (odds ratio 2.0, 95% confidence interval 1.0 to 3.9) but not with bacterial vaginosis diagnosed at 28 to 32 weeks' gestation (odds ratio 1.5, 95% confidence interval 0.7 to 3.0). The rates of preterm delivery were almost doubled for women who had bacterial vaginosis in early pregnancy (20.5%) as compared with women who had bacterial vaginosis only in late pregnancy (10.7%).

Conclusion: Only bacterial vaginosis diagnosed early in the second trimester of pregnancy plays a major role as a risk factor for preterm delivery.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Age Factors
  • Educational Status
  • Female
  • Gestational Age
  • Humans
  • Indonesia
  • Infant, Newborn
  • Obstetric Labor, Premature / microbiology*
  • Pregnancy
  • Risk Factors
  • Smoking
  • Time Factors
  • Trichomonas Infections
  • Vaginosis, Bacterial / complications*