Bayesian inference in multipoint gene mapping

Ann Hum Genet. 1993 Jan;57(1):65-82. doi: 10.1111/j.1469-1809.1993.tb00887.x.

Abstract

The problem of ordering and mapping genes on the basis of recombinant data and radiation hybrid data is formulated as a problem of Bayesian inference for an unknown permutation. The challenging computational problems posed by this approach are shown to be resolvable using Markov chain Monte Carlo methods.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Bayes Theorem*
  • Chromosome Mapping*
  • Female
  • Genetic Linkage
  • Humans
  • Male
  • Markov Chains
  • Models, Genetic
  • Monte Carlo Method
  • Recombination, Genetic