The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter

FEBS Lett. 1993 Jul 19;327(1):25-8. doi: 10.1016/0014-5793(93)81031-t.


The cAMP response element (CRE) and the CCAAT box of the fibronectin gene promoter are separated by only twenty base pairs. A specific factor that binds the CRE interacts cooperatively with the protein which binds to the adjacent CCAAT box, stimulating transcription [1992, J. Biol. Chem. 267, 12767-12774]. Here we show that the CRE factor is an heterodimer between a 43 kDa and the '73 kDa' CRE-binding proteins and we identify the latter as ATF-2 (also named CRE-BPI), a protein implicated in recruiting transcriptional activators to promoters, able to form heterodimers with Jun and for which a sequence-deduced MW of 55 kDa had been previously reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activating Transcription Factors
  • Animals
  • Base Sequence
  • Blood Proteins / genetics*
  • Cyclic AMP Response Element-Binding Protein / genetics*
  • Fibronectins / genetics*
  • Male
  • Molecular Sequence Data
  • Nuclear Proteins / genetics
  • Promoter Regions, Genetic*
  • Rats
  • Rats, Sprague-Dawley
  • Transcription Factors / genetics*
  • Transcription, Genetic


  • Activating Transcription Factors
  • Blood Proteins
  • Cyclic AMP Response Element-Binding Protein
  • Fibronectins
  • Nuclear Proteins
  • Transcription Factors