The distributions of subtypes of three serum proteins--alpha 1-antitrypsin, group-specific component and transferrin revealed by isoelectric focusing among Russian inhabitants of the Tomsk rural region are presented. Allele frequencies at the alpha 1-antitrypsin locus are as follows: M1--0.8450; M2--0.1125; M3--0.0350, the frequency of rare alleles being 0.0075. For the transferrin system gene frequencies are: C1--0.5528; C2--0.3920; C3--0.0302; B--0.0201; D--0.0050 and those for the group-specific component locus are: GclS--0.5175; Gc1F--0.1325; Gc2--0.3475 with 0.0025 for rare variants. Comparison with other ethnic groups of CIS was made.