Preventing acute gout when starting allopurinol therapy. Colchicine or NSAIDs?

Med J Aust. 1993 Aug 2;159(3):182-4.


Acute gout is a well known complication of the commencement of allopurinol therapy. Prophylaxis is needed for some months, even after serum urate levels have returned to normal. Colchicine is usually preferable to NSAIDs for this purpose, being cheaper, and better tolerated, especially in patients with peptic ulcer, gastrointestinal bleeding or dyspepsia or who are taking anticoagulants.

Publication types

  • Comparative Study

MeSH terms

  • Acute Disease
  • Allopurinol / therapeutic use*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Colchicine / administration & dosage
  • Colchicine / therapeutic use*
  • Drug Therapy, Combination
  • Gout / drug therapy*
  • Gout / prevention & control*
  • Humans


  • Anti-Inflammatory Agents, Non-Steroidal
  • Allopurinol
  • Colchicine